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Kaiser bIO-Optic

Continuous, inline, multi-component bioprocess measurement

The bIO-Optic is a versatile immersion optic used in conjunction with the Kaiser RamanRxn probehead. It measures multiple, specific bioprocessing components in real-time and is compatible with standard bioreactor ports. The fixed focus design of the Kaiser bIO-Optic provides long-term measurement stability along with superior signal performance, essential for transferable, high performance Raman-based bioprocess analysis. Available in various industry standard lengths, the bIO-Optic is ideally suited for both glass and plastic benchtop bioreactor/fermentor applications requiring headplate entry.

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Additional Components

Kaiser Raman Rxn2 Analyzer view from front left corner

Kaiser Raman Rxn2

Four channel Raman analyzer bridges laboratory analysis to the process environment

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Kaiser RamanRxn Probe front left view

Kaiser RamanRxn probehead

Laboratory probe, compatible with immersion and non-contact optics

Read More

Kaiser Raman Calibration Accessory product HCA

Kaiser Raman Calibration Accessory

Fast, simple, and accurate wavelength and intensity calibration for Raman analyzers

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Benefits

  • Immersion optic for multi-component bioprocess measurement
  • Compatible with standard bioreactor ports
  • Fixed-focus design
  • Available in 12 mm diameter with Pg 13.5 threaded connector
  • 120, 220, 320, or 420 mm lengths
  • Autoclavable

Field of Application

  • Cell culture: glucose, lactate, glutamine, amino acids, cell density, titer
  • Fermentation: glycerol, methanol, ethanol, sorbitol, biomass
  • Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients

Features and Specifications

Measurement principle
Raman

Laser wavelength
785 nm, 1000 nm

Probe compatibility
Kaiser RamanRxn probe

Sample interface
Temperature, bIO-Optic: –30°C to 150°C
Pressure: ≤200 psi

Body and wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: Pg 13.5
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible

Diameter (mm)
12

Lengths (mm)
120, 220, 320, or 420

Sterilization protocol compatibility
Autoclave

Process connection
Pg 13.5

Documents/ Manuals/Software

Brochures:

Application Notes:

bIO-PRO KS 785 Installed Lab with operator

NEWS

2020 Pharma Innovation Award

Our Kaiser Raman bIO-PRO, KS bioprocessing probe was recently selected as a 2020 Pharma Innovation Award winner by Pharma Manufacturing Magazine!

The Kaiser Raman bIO-PRO, KS probe provides fast, accurate measurement of key bioprocess variables from lab-to-process. It is an exciting advancement in our already well-established Kaiser Raman bioprocess product portfolio.

Read award announcement

Two employee with proper PPE and stainless steel Bio Reactor_resized

SUCCESS STORIES

Advanced bioprocess control

Learn how Kaiser Raman technology helped Nicro eliminate time-consuming offline sampling in favor of real-time monitoring of critical parameters in fermentation processes.

Read success story

2021 Coblentz Society William Wright award recipient, Dr. Ian Lewis

NEWS

2021 Williams-Wright Award

Dr. Ian R. Lewis, Director of Marketing at Kaiser Optical Systems, has been named the 2021 Williams-Wright Award recipient by The Coblentz Society for his significant contributions to vibrational spectroscopy. The award was presented during the 2021 Pittcon Conference & Expo.

Read award announcement