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Kaiser bIO-Optic

Continuous, inline, multi-component bioprocess measurement

The bIO-Optic is a versatile immersion optic used in conjunction with the Kaiser RamanRxn probehead. It measures multiple, specific bioprocessing components in real-time and is compatible with standard bioreactor ports. The fixed focus design of the Kaiser bIO-Optic provides long-term measurement stability along with superior signal performance, essential for transferable, high performance Raman-based bioprocess analysis. Available in various industry standard lengths, the bIO-Optic is ideally suited for both glass and plastic benchtop bioreactor/fermentor applications requiring headplate entry.

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Additional Components

Kaiser Raman Rxn2 Analyzer view from front left corner

Kaiser Raman Rxn2

Four channel Raman analyzer bridges laboratory analysis to the process environment

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Kaiser RamanRxn Probe front left view

Kaiser RamanRxn probehead

Laboratory probe, compatible with immersion and non-contact optics

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Kaiser Raman Calibration Accessory product HCA

Kaiser Raman Calibration Accessory

Fast, simple, and accurate wavelength and intensity calibration for Raman analyzers

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  • Immersion optic for multi-component bioprocess measurement
  • Compatible with standard bioreactor ports
  • Fixed-focus design
  • Available in 12 mm diameter with Pg 13.5 threaded connector
  • 120, 220, 320, or 420 mm lengths
  • Autoclavable

Field of Application

  • Cell culture: glucose, lactate, glutamine, amino acids, cell density, titer
  • Fermentation: glycerol, methanol, ethanol, sorbitol, biomass
  • Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients

Features and Specifications

Measurement principle

Laser wavelength
785 nm, 1000 nm

Probe compatibility
Kaiser RamanRxn probe

Sample interface
Temperature, bIO-Optic: –30°C to 150°C
Pressure: ≤200 psi

Body and wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: Pg 13.5
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible

Diameter (mm)

Lengths (mm)
120, 220, 320, or 420

Sterilization protocol compatibility

Process connection
Pg 13.5

Documents/ Manuals/Software


Application Notes:

bIO-PRO KS 785 Installed Lab with operator


2020 Pharma Innovation Award

Our Kaiser Raman bIO-PRO, KS bioprocessing probe was recently selected as a 2020 Pharma Innovation Award winner by Pharma Manufacturing Magazine!

The Kaiser Raman bIO-PRO, KS probe provides fast, accurate measurement of key bioprocess variables from lab-to-process. It is an exciting advancement in our already well-established Kaiser Raman bioprocess product portfolio.

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Two employee with proper PPE and stainless steel Bio Reactor_resized


Advanced bioprocess control

Learn how Kaiser Raman technology helped Nicro eliminate time-consuming offline sampling in favor of real-time monitoring of critical parameters in fermentation processes.

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2021 Coblentz Society William Wright award recipient, Dr. Ian Lewis


2021 Williams-Wright Award

Dr. Ian R. Lewis, Director of Marketing at Kaiser Optical Systems, has been named the 2021 Williams-Wright Award recipient by The Coblentz Society for his significant contributions to vibrational spectroscopy. The award was presented during the 2021 Pittcon Conference & Expo.

Read award announcement