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SUB Optic system

Kaiser Raman SUB Optic system

The Kaiser Raman SUB Optic system was developed according to industry standards for single-use sensors, is cGMP qualified, and is gamma sterilizable. Our biopharmaceutical customers depend on its sterility and reliability for single-use development and manufacturing.

The system is comprised of two parts:

  • Reusable optic, which is never in contact with the end product; and
  • A disposable fitting for single-use bioreactors (SUB), which is installed, tested, and supplied ready to use from the bioreactor vendor.

The Kaiser Raman SUB Optic system, in conjunction with the Kaiser RamanRxn probe, has been shown to offer the same quality data as reusable Raman probes. This ability allows customers to develop products and processes without limitations of the final production reactor type

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Additional Components


Kaiser Raman Rxn4

Process Raman analyzer ensuring 24/7 process and quality monitoring

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Kaiser Raman Rxn2 Analyzer view from front left corner

Kaiser Raman Rxn2

Four channel Raman analyzer bridges laboratory analysis to the process environment

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SUB-Optic System for Thermo Scientific™

Kaiser Raman enables PAT for single-use bioreactors and fermenters

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  • cGMP qualified
  • Gamma sterilizable
  • FDA-compatible window
  • Pre-aligned for best results straight out of the box
  • Long term measurement stability

Field of Application

  • Cell culture: glucose, lactate, amino acids, cell density, titer
  • Fermentation: glycerol, methanol, ethanol, sorbitol, biomass

Features and Specifications

Measuring principle

Laser wavelength
785 nm, 1000 nm

Sample Interface
Temperature, SUB-Optic: 0°C to 100°C

Body and wetted materials
Body: 316L stainless steel
Window: FDA-compatible window
Process connection: n/a (SUB ports provided by SUB vendor)
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible

Length (mm)
Overall length (SUB-Optic with Barb) : 129.5 (or 5.1″)
Insertion length (SUB-Barb only): 63.5 (or 2.5″)
RamanRxn probe head: 200

Diameter (mm)
SUB-Fitting: 12

Sterilization Protocol
Gamma irradiation (for bioprocess product contact parts only)

Documents/ Manuals/Software


Application Notes:


Feb 24, 2020 – Sartorius Introduces BioPAT® Spectro QbD Tool

The BioPAT® Spectro offers access to Raman spectroscopy analysis in high throughput process development, supporting faster Raman model building and accelerating scale-up into commercial manufacturing.

Read the full story

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10/23/2020 10:00 AM EST

Please join Dejan Arzenšek, Principal Scientist at Novartis and Maryann Cuellar from Kaiser Optical Systems, Inc. as they team up to discuss PAT tool mapping for enabling integrated DSP in continuous biomanufacturing, followed by an additional perspective on the biopharma industry.  The webinar is presented as part of  the BioPharma Asia Magazine webinar series.

Register Today!