SUB Optic system
Kaiser Raman SUB Optic system
The Kaiser Raman SUB Optic system was developed according to industry standards for single-use sensors, is cGMP qualified, and is gamma sterilizable. Our biopharmaceutical customers depend on its sterility and reliability for single-use development and manufacturing.
The system is comprised of two parts:
- Reusable optic, which is never in contact with the end product; and
- A disposable fitting for single-use bioreactors (SUB), which is installed, tested, and supplied ready to use from the bioreactor vendor.
The Kaiser Raman SUB Optic system, in conjunction with the Kaiser RamanRxn probe, has been shown to offer the same quality data as reusable Raman probes. This ability allows customers to develop products and processes without limitations of the final production reactor type
Additional Components
Kaiser Raman Rxn2
Four channel Raman analyzer bridges laboratory analysis to the process environment
SUB-Optic System for Thermo Scientific™
Kaiser Raman enables PAT for single-use bioreactors and fermenters
Benefits
- cGMP qualified
- Gamma sterilizable
- FDA-compatible window
- Pre-aligned for best results straight out of the box
- Long term measurement stability
Field of Application
- Cell culture: glucose, lactate, amino acids, cell density, titer
- Fermentation: glycerol, methanol, ethanol, sorbitol, biomass
Features and Specifications
Measuring principle
Raman
Laser wavelength
785 nm, 1000 nm
Sample Interface
Temperature, SUB-Optic: 0°C to 100°C
Body and wetted materials
Body: 316L stainless steel
Window: FDA-compatible window
Process connection: n/a (SUB ports provided by SUB vendor)
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible
Length (mm)
Overall length (SUB-Optic with Barb) : 129.5 (or 5.1″)
Insertion length (SUB-Barb only): 63.5 (or 2.5″)
RamanRxn probe head: 200
Diameter (mm)
SUB-Fitting: 12
Sterilization Protocol
Gamma irradiation (for bioprocess product contact parts only)
Documents/ Manuals/Software
Brochures:
Sampling Probes for Raman Spectroscopy Brochure
Real-time inline chemical monitoring & control for lab or process
Kaiser Raman Analyzers Brochure
Embedded control technology for reliable lab-to-process composition analysis
Application Notes:
NEWS
Feb 24, 2020 – Sartorius Introduces BioPAT® Spectro QbD Tool
The BioPAT® Spectro offers access to Raman spectroscopy analysis in high throughput process development, supporting faster Raman model building and accelerating scale-up into commercial manufacturing.
EVENTS
10/23/2020 10:00 AM EST
Please join Dejan Arzenšek, Principal Scientist at Novartis and Maryann Cuellar from Kaiser Optical Systems, Inc. as they team up to discuss PAT tool mapping for enabling integrated DSP in continuous biomanufacturing, followed by an additional perspective on the biopharma industry. The webinar is presented as part of the BioPharma Asia Magazine webinar series.