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SUB Optic system

Kaiser Raman SUB Optic system

The Kaiser Raman SUB Optic system was developed according to industry standards for single-use sensors, is cGMP qualified, and is gamma sterilizable. Our biopharmaceutical customers depend on its sterility and reliability for single-use development and manufacturing.

The system is comprised of two parts:

  • Reusable optic, which is never in contact with the end product; and
  • A disposable fitting for single-use bioreactors (SUB), which is installed, tested, and supplied ready to use from the bioreactor vendor.

The Kaiser Raman SUB Optic system, in conjunction with the Kaiser RamanRxn probe, has been shown to offer the same quality data as reusable Raman probes. This ability allows customers to develop products and processes without limitations of the final production reactor type.

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SUB-Optic System for Thermo Scientific™

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  • Disposable fitting for single-use bioreactors (SUB), plus a non-contact reusable optic
  • Developed to industry standards for single-use sensors
  • Gamma sterilizable
  • Tested and supplied by multiple SUB vendors

Field of Application

  • Cell culture: glucose, lactate, amino acids, cell density, titer
  • Fermentation: glycerol, methanol, ethanol, sorbitol, biomass

Features and Specifications

Measuring principle

Laser wavelength
785 nm, 1000 nm

Sample Interface
Temperature, SUB-Optic: 0°C to 100°C

Wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: n/a (SUB ports provided by SUB vendor)
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible

Length (mm)
Overall length (SUB-Optic with Barb) : 129.5 (or 5.1″)
Insertion length (SUB-Barb only): 63.5 (or 2.5″)

Immersible diameter (mm)
SUB-barb diameter: 15.7-11.7 tapered

Sterilization Protocol
Gamma irradiation (for bioprocess product contact parts only)

Documents/ Manuals/Software


Application Notes:

Globe with pills white background and blue


IFPAC-2021 (February 28 – March 5, 2021)

Join us for our three virtual presentations at IFPAC-2021:

March 1st at 1-5:30 PM EST – SmartRaman spectroscopy for automated monitoring and control of industrial processes

March 2nd at 1-5:30 PM EST – Tips and tricks to make process Raman spectroscopy a success

March 4th at 7:45-11:00 AM EST – Raman spectroscopy for automated monitoring and control of bioprocesses

Register today

bIO-PRO KS 785 Installed Lab with operator


2020 Pharma Innovation Award

Our Kaiser Raman bIO-PRO, KS bioprocessing probe was recently selected as a 2020 Pharma Innovation Award winner by Pharma Manufacturing Magazine!

The Kaiser Raman bIO-PRO, KS probe provides fast, accurate measurement of key bioprocess variables from lab-to-process. It is an exciting advancement in our already well-established Kaiser Raman bioprocess product portfolio.

Read the award announcement

Pittcon 2021 virtual conference


2021 Pittcon Conference & Expo (March 8-12, 2021)

Join us during our two virtual presentations at the 2021 Pittcon Conference & Expo:

March 8th at 1:30 PM EST – The Role of Process Raman Spectroscopy in Chemical and Polymer Applications

March 12 at 9:30 AM EST – Analytical Model Development for Raman Spectroscopy of Pharmaceutical Solids Processing and Upstream Bioprocessing

Register today