SUB Optic system
Kaiser Raman SUB Optic system
The Kaiser Raman SUB Optic system was developed according to industry standards for single-use sensors, is cGMP qualified, and is gamma sterilizable. Our biopharmaceutical customers depend on its sterility and reliability for single-use development and manufacturing.
The system is comprised of two parts:
- Reusable optic, which is never in contact with the end product; and
- A disposable fitting for single-use bioreactors (SUB), which is installed, tested, and supplied ready to use from the bioreactor vendor.
The Kaiser Raman SUB Optic system, in conjunction with the Kaiser RamanRxn probe, has been shown to offer the same quality data as reusable Raman probes. This ability allows customers to develop products and processes without limitations of the final production reactor type.
Additional Components

Kaiser Raman Rxn2
Four channel Raman analyzer bridges laboratory analysis to the process environment

SUB-Optic System for Thermo Scientific™
Kaiser Raman enables PAT for single-use bioreactors and fermenters
Benefits
- Disposable fitting for single-use bioreactors (SUB), plus a non-contact reusable optic
- Developed to industry standards for single-use sensors
- Gamma sterilizable
- Tested and supplied by multiple SUB vendors
Field of Application
- Cell culture: glucose, lactate, amino acids, cell density, titer
- Fermentation: glycerol, methanol, ethanol, sorbitol, biomass
Features and Specifications
Measuring principle
Raman
Laser wavelength
785 nm, 1000 nm
Sample Interface
Temperature, SUB-Optic: 0°C to 100°C
Wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: n/a (SUB ports provided by SUB vendor)
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible
Length (mm)
Overall length (SUB-Optic with Barb) : 129.5 (or 5.1″)
Insertion length (SUB-Barb only): 63.5 (or 2.5″)
Immersible diameter (mm)
SUB-barb diameter: 15.7-11.7 tapered
Sterilization Protocol
Gamma irradiation (for bioprocess product contact parts only)
Documents/ Manuals/Software
Brochures:
Kaiser Raman Probes brochure
Robust optical measurement of chemical composition
Kaiser Raman Analyzers brochure
Robust optical measurement of chemical composition
Application Notes:

EVENTS
IFPAC-2021 (February 28 – March 5, 2021)
Join us for our three virtual presentations at IFPAC-2021:
March 1st at 1-5:30 PM EST – Smart‐Raman spectroscopy for automated monitoring and control of industrial processes
March 2nd at 1-5:30 PM EST – Tips and tricks to make process Raman spectroscopy a success
March 4th at 7:45-11:00 AM EST – Raman spectroscopy for automated monitoring and control of bioprocesses

NEWS
2020 Pharma Innovation Award
Our Kaiser Raman bIO-PRO, KS bioprocessing probe was recently selected as a 2020 Pharma Innovation Award winner by Pharma Manufacturing Magazine!
The Kaiser Raman bIO-PRO, KS probe provides fast, accurate measurement of key bioprocess variables from lab-to-process. It is an exciting advancement in our already well-established Kaiser Raman bioprocess product portfolio.

EVENTS
2021 Pittcon Conference & Expo (March 8-12, 2021)
Join us during our two virtual presentations at the 2021 Pittcon Conference & Expo:
March 8th at 1:30 PM EST – The Role of Process Raman Spectroscopy in Chemical and Polymer Applications
March 12 at 9:30 AM EST – Analytical Model Development for Raman Spectroscopy of Pharmaceutical Solids Processing and Upstream Bioprocessing