Products Kaiser Raman probes bIO-PRO, KS probe

Kaiser Raman bIO-PRO, KS probe

The Kaiser Raman bIO-PRO, KS bioprocess probe has been adapted to fit the BioPAT® Spectro platform by Sartorius

The recent union between Kaiser Raman analyzers equipped with bioprocess probe technology and the BioPAT® Spectro platform by Sartorius offers the market an ideal interface to high throughput development through single-use commercial manufacturing. Kaiser Raman’s bioprocessing probe technology has been adapted to fit Sartorius’s BioPAT® Spectro platform​, utilizing the same Kaiser Raman probe design for Ambr® 15, Ambr® 250, & Biostat STR® bioreactors​. Compatibility with BioPAT® Spectro from Sartorius is an exciting advancement in the already well-established Kaiser Raman bioprocessing product portfolio.

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Additional Components

Kaiser Raman Rxn2 Analyzer view from front left corner

Kaiser Raman Rxn2

Raman analyzer bridging laboratory analysis to the process environment

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Kaiser Raman Rxn4 analyzer front

Kaiser Raman Rxn4

Process Raman analyzer ensuring 24/7 process and quality monitoring

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Kaiser Raman bIO-PRO KS Installed with operator hands

BioPAT® Spectro by Sartorius

Find out about Kaiser Raman’s exciting collaboration with Sartorius in bioprocessing

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  • Enables faster, easier, and more robust model building via integration with Ambr® 15 and Ambr® 250
  • Allows high throughput process development which supports QbD
  • Provides a more efficient transfer to Biostat STR® for single-use manufacturing
  • Offers a scale-independent interface from 15 ml in the laboratory to 2000 L in the production suite
  • Requires no probe cleaning, sterilization, or frequent maintenance due to non-contact sampling

Field of Application

  • Cell culture: glucose, lactate, amino acids, cell density, titer, and more

Features and Specifications

Ambr®: Kaiser Raman Rxn2 single-channel
Biostat STR®: Embedded or non-embedded Kaiser Raman Rxn2 or Rxn4 analyzers

Installation configuration
Ambr®: Benchtop
Biostat STR®: Benchtop or mobile wheeled cart (Raman Rxn2); rack mounted or NEMA 4x enclosure (Raman Rxn4)

Spectral coverage
150-3425 cm-1 (λ=785 nm)

Laser wavelength
785 nm

Maximum laser power into probe
<499 mW

Probe configuration software
Ambr®: Single-channel
Biostat STR®: Up to four channels

Raman RunTime v6.2+

User interface
Touch screen starter kit

Fiber optic cable
Ambr®: 5m EO to EO fiber cable
Biostat STR®: EO to EO fiber cable (standard or custom length); or FC to EO fiber converter(s) for non-embedded systems

Kaiser Raman probe calibration accessories
Ambr®: Ambr® flow cell light shield (sold by Kaiser)
Biostat STR®: SIMCA-Q v16 predictor (available for purchase in Raman RunTime v6.2+ software); BioPAT® Spectro Support (locking mechanism from Sartorius)

Documents/ Manuals/Software

Data Sheet:


Application Notes:

bIO-PRO KS 785 Installed Lab with operator


2020 Pharma Innovation Award

Our Kaiser Raman bIO-PRO, KS bioprocessing probe was recently selected as a 2020 Pharma Innovation Award winner by Pharma Manufacturing Magazine!

The Kaiser Raman bIO-PRO, KS probe provides fast, accurate measurement of key bioprocess variables from lab-to-process. It is an exciting advancement in our already well-established Kaiser Raman bioprocess product portfolio.

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Two employee with proper PPE and stainless steel Bio Reactor_resized


Advanced bioprocess control

Learn how Kaiser Raman technology helped Nicro eliminate time-consuming offline sampling in favor of real-time monitoring of critical parameters in fermentation processes.

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2021 Coblentz Society William Wright award recipient, Dr. Ian Lewis


2021 Williams-Wright Award

Dr. Ian R. Lewis, Director of Marketing at Kaiser Optical Systems, has been named the 2021 Williams-Wright Award recipient by The Coblentz Society for his significant contributions to vibrational spectroscopy. The award was presented during the 2021 Pittcon Conference & Expo.

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