Products Kaiser Raman probes bIO-PRO probe

Kaiser Raman bIO-PRO probe

The ultimate in compatibility for bioprocess manufacturing

In order to capitalize on the power of Raman in manufacturing it is necessary to meet the sampling requirements of compliance, sterilization, port compatibility, and convenience. The Kaiser Raman bIO-PRO probe:

  • Offers a suitable surface finish for GMP manufacturing
  • Is compatible with side ports of large bioreactors
  • Meets CIP/SIP sterilization protocols.

The bIO-PRO may be installed in development reactors of up to 50 L  and in production reactors up to  20,000 L. In addition to applications in bioprocessing, the bIO-PRO design may also be successfully used in food and beverage to provide an analytical “eye” into the fermentation process.

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Additional Components

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Process Raman analyzer ensuring 24/7 process and quality monitoring

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Kaiser Calibration Accessory product

Kaiser Raman Calibration Accessory

Fast, simple, and accurate wavelength and intensity calibration for Raman analyzers

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  • Compatible with standard bioreactor side ports
  • Compatible with CIP/SIP sterilization protocols
  • Pre-align for best results straight out of the box
  • Long term measurement stability

Field of Application

  • Cell culture: glucose, lactate, amino acids, cell density, titer
  • Fermentation: glycerol, methanol, ethanol, sorbitol, biomass

Features and Specifications

Measuring principle

Laser wavelength
785 nm, 1000 nm

Spectral coverage
150-3425 cm-1 (λ=785 nm); 200-2400 cm-1 (λ=1000 nm)

Maximum laser power into probe
<499 mW

Sample interface
Temperature: –30°C to 150°C
Pressure: ≤200 psi

Body and wetted materials
Body: 316L stainless steel
Window: FDA-compatible window
Process connection: Pg 13.5, standard housings (i.e. Ingold, NA Connect)
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993

Fiber optic cable interface
Kaiser EO Connectors
IP 65 rugged probe to cable interface

Length (mm)
Insertion length: 120
Probe dimensions: 306 x 127 x 34

Diameter (mm)

Sterilization protocol compatibility

Documents/ Manuals/Software


Application Notes:


Feb 24, 2020 – Sartorius Introduces BioPAT® Spectro QbD Tool

The BioPAT® Spectro offers access to Raman spectroscopy analysis in high throughput process development, supporting faster Raman model building and accelerating scale-up into commercial manufacturing.

Read the full story

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10/23/2020 10:00 AM EST

Please join Dejan Arzenšek, Principal Scientist at Novartis and Maryann Cuellar from Kaiser Optical Systems, Inc. as they team up to discuss PAT tool mapping for enabling integrated DSP in continuous biomanufacturing, followed by an additional perspective on the biopharma industry.  The webinar is presented as part of  the BioPharma Asia Magazine webinar series.

Register Today!